In PC, one of the most prominently expressed chemokines is CXCL8, which also plays a significant role in tumor invasion, angiogenesis, and metastasis; therefore, Jin et al. engineered and evaluated CXCR1-CD70 and CXCR2-CD70 CAR-T cells in human pancreatic carcinoma cell line PANC-1, as well as in vivo in mice inoculated with PANC-1.i720 tumor cells. Here, CXCR1 is linked to pachyonychia congenita.