PC is associated with numerous risk factors, including age, sex, tobacco smoking, overweight and obesity, hyperglycemia, insulin resistance, type 2 diabetes, pancreatitis, as well as genetic factors (mutations in BRCA1, BRCA2, PALB2, ATM, STK11/LKB1, P16INK4A/CDKN2A, KRAS5, and TP53 genes) [5]. This evidence concerns the gene CDKN2A and pachyonychia congenita.