TGFB1 and neoplasm: Apart from direct ECM remodeling, cancer cells can recruit and activate stromal cells, which are major players in ECM deposition events and are located in the tumor microenvironment via the release of various pro-fibrotic growth factors and inflammatory factors such as epidermal growth factor (EGF), fibroblast growth factor (FGF)-2, platelet-derived growth factor (PDGF) TGF-α, and TGF-β [270].