In the cisplatin-sensitive BRCA2 mouse model of pancreatic ductal adenocarcinoma (PDA), the change in volume of the tumor following treatment with cisplatin demonstrated that the disease stabilized or overtly relapsed, which was associated with reduced tumor stiffness, indicating that the successful treatment response to chemotherapy was associated with diminished tumor stiffness in this animal model [176]. The gene discussed is BRCA2; the disease is neoplasm.