MAPT and Alzheimer disease: AD is a pathologically multifactorial disease, and many factors are proposed to contribute to the pathogenesis and progression of AD such as amyloid-beta (Aβ) protein deposits and neurofibrillary tangles (NFT) induced by tau protein hyperphosphorylation, in association with synapse loss, neuronal cell death, chronic neuroinflammation, etc., [1,2].