In a very recent mouse model, Yang et al. reported that coexpression of Nurr1 with its co-factor forkhead box protein A2 (Foxa2) using adeno-associated virus serotype 9 (AAV9)-mediated gene delivery in the cranium could efficiently attenuate Aβ-induced neuroinflammation, promote the expression of neurotrophic factors, and improve the cognitive dysfunction of AD, which provides an additional disease-modifying treatment strategy for AD therapy [42]. The gene discussed is NR4A2; the disease is Alzheimer disease.