MAP3K5 and Alzheimer disease: A study conducted by Sun et al. showed FBXW11, a component of the SCF E3 ubiquitin ligase complex, was overexpressed in Aβ-stimulated microglia cells and the hippocampus of AD mice, and it enabled the activation of the ASK1/MAPKs/NF-κB inflammatory signaling pathway, thereby contributing to inflammation-induced AD pathology.