Hur et al. found that pro-inflammatory cytokines are able to induce the generation of interferon-induced transmembrane protein 3 (IFITM3) in neurons and astrocytes, which forms a complex with γ-secretase to thereby promote Aβ generation, providing a new mechanistic insight into inflammation-mediated Aβ production to drive AD pathology and progression [45]. Here, IFITM3 is linked to Alzheimer disease.