Ferrari et al. [26] reported that DKK-3 interacts physically with Kremen-1 in human breast cancer–cancer-associated fibroblasts (BC-CAFs) and co-localizes in internal structures, leading to Kremen-1 destabilization, LRP5/6 stabilization and activation of Wnt signaling in a cell-autonomous manner. This evidence concerns the gene LRP5 and breast cancer.