Analyzing sorted LECs from HFD-fed C57BL/6J obesity-prone mice showed that the expression of VEGFR3 is decreased in obesity, while HFD-fed BALB/cJ and myostatin null (MSTNln) obesity-resistant mice had no significant changes to their lymphatics [159,160,161]. The gene discussed is FLT4; the disease is obesity due to melanocortin 4 receptor deficiency.