AXIN2 and cancer: As a consequence, we observed a significant downregulation of several WNT target genes, including canonical WNT marker genes: AXIN2 (axis inhibition protein 2), CCND1, encoding the cell cycle regulator cyclin D1, and LGR5 (G-protein coupled receptor 5) that is also known as a bona fide cancer stem cell marker [24] (Figure 3).