In cell culture experiments, estradiol and diethylstilbestrol killed PCa cells with different experiments, suggesting that this additional effect was due to the activation of different microtubule-associated proteins (MAPs) that generate signaling cascades for the production of either reactive oxygen species (ROS) or induction of caspases, leading to necrosis or apoptosis, respectively [48]. Here, C3orf62 is linked to posterior cortical atrophy.