To gain an insight on the involvement of DHRS7 in PCa, we used two PCa model cell lines: LNCaP that was established from a metastatic lesion in a lymph node and is androgen-dependent [25,28,29,30,31,32]; and PC3 that is derived from a PCa lumbar metastatic lesion and is androgen-independent [33]. Here, DHRS7 is linked to posterior cortical atrophy.