An in vitro study of NSCLC cell lines showed that almonertinib significantly inhibits H1975 (EGFR-resistant mutation: L858R/T790M mutation) and HCC827 (EGFR-sensitive mutation: E746-A750 deletion) cell colony formation rather than A549 cells (wt EGFR) and induced the apoptosis in H1975 and HCC827 cells in a dose-dependent manner rather than A549 cells [167]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.