A TERT mutation identification could not be sufficient to assume that the tumor will behave as glioblastoma, IDH-wildtype (WHO CNS grade 4) as proposed in the cIMPACT-NOW update 6 [40] and it may be too late for the results of this paper to be incorporated in the upcoming 2021 WHO classification for CNS Tumor. This evidence concerns the gene TERT and central nervous system neoplasm.