RUNX1 and acute leukemia: Several TFs have been reported to regulate KIT, including Sp1, GATA2, Runt-related transcription factor 1 (RUNX1), Stem cell leukemia (SCL), Lim-only 2 (LMO2), and GATA-1/GATA-2 [18,19,20,21], although the precise binding motifs in the KIT promoter, to which these factors bind, vary between cells, as exemplified by a comparison between hematopoietic stem/progenitor cells and MCs [22].