VEGFA and nonpapillary renal cell carcinoma: An early critical event in ccRCC pathogenesis is the mutation or inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene [9], resulting in the aberrant accumulation of hypoxia-inducible factors (HIFs) and the activation of pro-angiogenic signaling cascades, notably the vascular endothelial growth factor (VEGF) pathway [9,10].