ADORA2A and schizophrenia: A2AR mRNA expression (t(22) = −2.578, p = 0.017), but not A1R mRNA expression (t(22) = −1.943, p = 0.065), was also significantly increased in schizophrenia subjects “off” medication compared to non-psychiatrically-ill control subjects, suggesting a disease-related increase in A2AR mRNA expression that may be normalized by antipsychotic treatment (Supplementary Figure S3C,D).