In addition, an EGFR/HER2-targeting vaccine, utilizing a portion of the canine EGFR (p527-545), a conserved extracellular domain of EGFR and homologous to HER2 and HER3 extracellular domains, along with vaccination for borrelia burgdorferi antigen as an adjuvant, has been tested in 43 dogs with appendicular OSA overexpressing EGFR and showed some positive results. The gene discussed is ERBB2; the disease is obstructive sleep apnea syndrome.