The three OSA cell lines showed downregulated gene expression of CDKN2A (which encodes p16INK4a), CDKN2B, THBS1, PTHLH, CDKN1A, CCND1 and CCND3 and upregulated expression of CXCR4, BIRC5, RAD51, CDKN2C, BCL2, BRCA1, PCNA and CHEK2. The gene discussed is THBS1; the disease is obstructive sleep apnea syndrome.