The three OSA cell lines showed downregulated gene expression of CDKN2A (which encodes p16INK4a), CDKN2B, THBS1, PTHLH, CDKN1A, CCND1 and CCND3 and upregulated expression of CXCR4, BIRC5, RAD51, CDKN2C, BCL2, BRCA1, PCNA and CHEK2. This evidence concerns the gene CDKN1A and obstructive sleep apnea syndrome.