These results align with ours, including increased expression of Arg-1, Mrc-1 (CD206) and secretion of TGFβ in NLRX1 KO mice, indicating a promising role of NLRX1 in limiting pro-fibrotic macrophage polarization during the development of renal fibrosis induced by UUO. The gene discussed is MRC1; the disease is renal fibrosis.