Lastly, although the cDC1 and cDC2 are able to mature, infection with ECTV leads to a decline in the ability of the cDC subsets of both mouse strains to stimulate proliferation and the production of Th1- and Th2-polarizing cytokines by allogeneic CD4+ T cells of C3H mice, compared to that of DC subsets of uninfected animals. The gene discussed is MPPE1; the disease is infection.