In our latest studies, we investigated the impact of deletion of either VDR or PDIA3 on gene expression profile and non-genomic effects of 1,25(OH)2D3 in A431 squamous cell carcinoma, showing that PDIA3 is involved in genomic responses to 1,25(OH)2D3 [13,22]. This evidence concerns the gene VDR and squamous cell carcinoma.