GPC1 and familial pancreatic carcinoma: While Kleeff et al. (1998) reported that GPC-1 was highly expressed in both cancer cells and fibroblasts in human pancreatic cancer samples [127], Melo et al. (2015) found that GPC-1 was enriched on exosomes derived from tumour cells and could be detected in serum with a staggering 100% SN and SP [25] (Table 1).