Fabijanovic et al. [22] showed that the expression of SFRP1 in seminomas and mixed or nonseminomas was lower in atrophied tissues compared with benign tissues, and SFRP1 appeared to be actively involved in the pathogenesis of primary testicular germ cell tumors, indicating that the downregulation of SFRP1 was actively involved in the regulation of testicular development. Here, SFRP1 is linked to seminoma.