YAP1 and infectious disease: In the interaction of five gene protein networks that regulate bacterial infectious disease signaling, the transcription factor YAP-1/YAP is activated when Pseudomonas aeruginosa infects the intestinal barrier of worms; the deletion of YAP-1 significantly reduces the survival rate of worms and increases the accumulation of bacteria in the host, which deploys pathogen defenses when it recognizes the loss of the intestinal epithelial barrier [49].