A study of canine eyes with acute (≤5 days from clinical signs) or chronic (>5 days) PACG showed glaucoma-related disruption of retinal pigmented epithelium (RPE), increased permeability of the retinal vascular endothelium, pigmentary dispersion, accumulation of inflammatory cells within the neuroretina and vitreous body, as well as accumulation of serum albumin around retinal blood vessels [18]. This evidence concerns the gene ALB and glaucoma.