SLC5A2 and obesity due to melanocortin 4 receptor deficiency: To assess this hypothesis and to specifically explore the role of ANT2 in modulating kidney and mitochondrial function in obesity, we generated RPTC-specific ANT2-null mice (RPTC-ANT2−/−) by crossing ANT2-floxed mice30 with transgenic iL1-Sglt2-Cre mice,31 in which Cre recombinase is expressed in the nucleus of the S1 segment of the proximal tubule (Supplemental Figure 1I).