To assess this hypothesis and to specifically explore the role of ANT2 in modulating kidney and mitochondrial function in obesity, we generated RPTC-specific ANT2-null mice (RPTC-ANT2−/−) by crossing ANT2-floxed mice30 with transgenic iL1-Sglt2-Cre mice,31 in which Cre recombinase is expressed in the nucleus of the S1 segment of the proximal tubule (Supplemental Figure 1I). This evidence concerns the gene SLC25A5 and obesity disorder.