While the former has been extensively studied in gastric cancer, with CAFs-secreted paracrine factors such as Lumican [33], IL-8 [34], WNT5A [35], extracellular vesicles [36], and others promoting tumor progression, the contribution of CAFs-gastric cancer cell juxtacrine signaling to gastric cancer progression remains unclear. The gene discussed is LUM; the disease is gastric cancer.