In univariate Cox regression analysis, history of viral hepatitis B, hepatolithiasis, Aspartate Aminotransferase (AST), bilirubin, Carcinoembryonic antigen (CEA), Carbohydrate antigen 19–9 (CA19-9), tumor differentiation, vascular invasion, perineural invasion, lymph node invasion, tumor number, tumor size, HALP, TBS, and HTS grade were each found to be influencing factors for OS (Table 3). Here, CEACAM5 is linked to hepatitis B virus infection.