Among the top downregulated 50 genes, there were other cancer relevant genes such as cell cycle associated (CCNF1, CCNB1, ZWINT), cancer signaling (STK32B, IGF1, FLT1) and splicing associated (HNRNPM, HNRNPU, SRSF1) genes, which are active areas to investigate further. This evidence concerns the gene IGF1 and cancer.