A recent investigation has implicated ALCAT1, which is responsible for the pathological remodelling of cardiolipin with long-chain polyunsaturated fatty acids, in mitochondrial abnormalities in several diseases, including myocardial infarction, Parkinson’s disease, diet-induced obesity and other ageing-related diseases [15, 19, 22, 26]. The gene discussed is LCLAT1; the disease is myocardial infarction.