ATP7A and cancer: Aubert, L. et al. found that copper content was significantly elevated in KRAS mutant cells; this was due to the high expression of ATP7A in cancer cells, which reduced the sensitivity of cells to increase the copper; ATP7A is mostly present on the cell surface, maintains stable intracellular copper levels, and protects cancer cells from copper ion toxicity, thereby reducing the occurrence of cuproptosis [21].