TP53 and neoplasm: In ferroptosis, P53 also promotes the emergence of a new pattern of ferroptosis, and it has been shown that P53 can damage GSH in the event of oxidative stress by inhibiting the expression of the SLC7A11 gene [8], reduce the cell uptake of cystine, reduce the cellular antioxidant capacity, thereby promoting ferroptosis in tumor cells, and inhibit ferroptosis by negatively regulating dipeptidyl peptidase-4 (DDP-4) [36].