Yao X et al. [85] showed that upregulated LDHA increased the lactate content and promoted the lactylation of histone H3K18la, which was significantly enriched on the HMGB1 promoter and upregulated HMGB1 expression, hence inducing cell pyroptosis and aggravating cerebral ischemia-reperfusion injury. This evidence concerns the gene HMGB1 and brain ischemia.