CSF3 and infection: Additionally, on the plus side is the fact that increased lactate release within an infection context mediates signal transduction of the bone marrow endothelial lactate-receptor GPR81, thereby preferably promoting neutrophil mobilization by regulating the expression of endothelial VE-Cadherin and further vascular permeability in bone marrow as well as inducing the release of neutrophil mobilizers such as granulocyte colony-stimulating factor (G-CSF) [39].