In nasopharyngeal carcinoma, exosomes are highly enriched in intercellular adhesion molecule-1 (ICAM-1), CD44 variant isoform 5 (CD44v5) and matrix metalloproteinase 13 (MMP-13), in contrast, angio-suppressive protein TSP-1 is downregulated in these exosomes [138, 139]. This evidence concerns the gene THBS1 and nasopharyngeal carcinoma.