In lung adenocarcinoma, exosomes enriched in sortilin (also known as neurotensin receptor 3, NTSR3) might upregulate the level of expression of some pro-angiogenic proteins, namely endothelin-1, IL-8, thrombospondin-2 (TSP-2), uPA, and VEGF. This evidence concerns the gene THBS2 and lung adenocarcinoma.