TIMP3 and metastatic melanoma: These molecules include H-Ras (Harvey rat sarcoma virus), N-Ras (Neuroblastoma RAS viral oncogene homolog), GANAB (glucosidase II alpha subunit), HSP90B1 (heat shock protein 90 beta family member 1), TIMP3 (tissue inhibitor of metalloproteinase-3) and other proteins, which are also linked to metastatic melanoma patient’s poor prognosis [70, 103].