Mean free aflibercept and adjusted bound Cmax in pediatric patients with ROP after 0.4 mg/eye intravitreal administration are approximately 80 times and 1.8 times lower, respectively, than that for the 2 mg/kg intravenous dose in adults, while baseline systemic VEGF concentrations are much higher in patients with ROP than healthy adults [34–37]. The gene discussed is VEGFA; the disease is retinopathy of prematurity.