Overall, 35 DDR genes were recurrently targeted in the tumour cohort, including well-established tumour suppressors such as Brca2 and Palb2, and mismatch repair pathway genes such as Mlh1, Pms1 and Msh6. The most frequently targeted genes were Mre11, Neil3, 53bp1, Lmo4, Xrcc6, Alkbh2, Brca2, Mlh1 and Pcna (Fig. 1e,f). This evidence concerns the gene MSH6 and neoplasm.