However, in the same SLC22A4 candidate region as rs35260072, we find that the frequency of the previously reported allele rs1050152: T (which also protects against asthma (OR 0.90; ref. 48) and related infections) plateaued about 1,500 years ago, contrary to previous reports suggesting a recent rise in frequency7. The gene discussed is SLC22A4; the disease is infection.