Within individual cancer types, the frequency of TP53 mutations was variable but highest in uterine corpus endometrial serous carcinoma, ovarian high-grade serous carcinoma, lung squamous cell carcinoma, rectum adenocarcinoma, esophageal adenocarcinoma and esophageal squamous cell carcinoma (more than 70% of cases). The gene discussed is TP53; the disease is esophageal adenocarcinoma.