In 2007, Jass et al. [3] described the molecular heterogeneity of CRC based on the presence or absence of chromosomal instability (CIN), microsatellite instability/mismatch repair deficiency (MSI/MMRd), CpG island methylator phenotype (CIMP), BRAF c.1799T>A p.Val600Glu (BRAF p.V600E), KRAS somatic mutations in codons 12 and 13 and germline pathogenic variants in the DNA MMR genes (Lynch syndrome). Here, BRAF is linked to colorectal carcinoma.