In 2007, Jass et al. [3] described the molecular heterogeneity of CRC based on the presence or absence of chromosomal instability (CIN), microsatellite instability/mismatch repair deficiency (MSI/MMRd), CpG island methylator phenotype (CIMP), BRAF c.1799T>A p.Val600Glu (BRAF p.V600E), KRAS somatic mutations in codons 12 and 13 and germline pathogenic variants in the DNA MMR genes (Lynch syndrome). This evidence concerns the gene BRAF and Lynch syndrome.