Terlouw et al. [20], identified the APC: c.835-8 A > G mutation in premalignant adenomas from people with unexplained adenomatous polyposis supporting this mutation and colibactin-induced DNA damage as an early event in tumorigenesis, although further studies are needed to help elucidate this bacteria’s driver role during CRC development. This evidence concerns the gene APC and colorectal carcinoma.