This investigation corroborates several previous observations, including those which demonstrated ANXA1 expression in the metastatic TNBC cell line MDA-MB-231 was linked to enhanced cell proliferation and cell cycle transition [16] and that a decrease in cell proliferation was associated with G1 phase cell cycle arrest following ANXA1 knockdown via siRNA in pancreatic cancer cell lines [15, 34, 35]. This evidence concerns the gene ANXA1 and familial pancreatic carcinoma.