ARHGEF2 and colitis: Seven weeks post-transfer, histology of colon sections revealed no difference between B6 and Arhgef2−/−, including a similar CD3+ T cells infiltration (Supplementary Fig. 4a) and pathology score (Supplementary Fig. 4b), suggesting that the exacerbated colitis response to DSS seen in Arhgef2−/− mice (Fig. 4) was not lymphoid in nature.