Subsequently, we showed that (1) Ccdc88b inactivation also protects against inflammation in experimental colitis13, (2) CCDC88B is the human gene underlying the 11q13 locus associated with susceptibility to several inflammatory conditions, including IBD6,13, and (3) CCDC88B mRNA is regulated by cis-acting elements in human myeloid cells, and CCDC88B mRNA expression is positively correlated with disease risk in Crohn’s disease patients6,13. Here, CCDC88B is linked to Crohn disease.