ARHGEF2 and colorectal carcinoma: We note that as opposed to Arhgef2−/− mice that behaved like controls, Rasal3−/− mice showed a significantly greater susceptibility to CA-CRC; this susceptibility was expressed both by an increase in the total number of tumors per colon (Supplementary Fig. 5a, b), and an increase total tumor surface area (Supplementary Fig. 5c).