In addition, mutant Rasal3−/− mice show enhanced susceptibility to DSS-colitis, which is similar to Arhgef2 mutants (Fig. 4), including enhanced pathological scores, expression of inflammatory cytokine markers, and presence of CD45+ cellular infiltrate in the lamina propria and dominated by CD11b+/Ly6G+ granulocytes. Here, ARHGEF2 is linked to colitis.