Then, we explored the frequencies of these two clusters in scRNA-seq data14 from vitiligo lesions and healthy skin, and found a decrease in the proportion of LAMB3+ basal keratinocytes in lesions (lesions vs. normal skin: 3.19% vs. 4.32%, P > 0.05) and no difference in the proportion of ZNF90+ fibroblasts (lesions vs. normal skin: 1.12% vs. 0.63%, P < 0.05) (Supplementary Fig. S5a), which may reflect the correlation between these two clusters of cells and skin pigmentation. The gene discussed is LAMB3; the disease is vitiligo.