This is consistent with a previous study which demonstrated that unlike BAD which is largely localized to cytoplasm, phosphorylated BAD, especially at Serine 99 (murine Serine 136) exhibits largely nuclear localization in cancer tissues of ER+PR+HER2+ , ER+PR+HER2- and ER-PR-HER2- BC patients24. This evidence concerns the gene ESR1 and breast cancer.