We find that reduced MST4 expression in GABAergic neurons in the CeA (GABACeA) contributes to the increased release of CX3CL1, inducing microglial activation, which in turn increases the engulfment of GABACeA neuronal spines, thereby reducing GABACeA neuronal activity and alleviating anxiety-like behaviors within 12 hours after acute restraint stress. The gene discussed is CX3CL1; the disease is Anxiety.