NFKB1 and Anxiety: These cumulative findings suggest that a decrease in MST4 expression after acute restraint stress results in the activation of NF-κB-CX3CL1 signaling in GABACeA neurons, which in turn promotes microglial activation and engulfment of GABACeA neuronal spines, leading to the recovery of GABACeA neuronal hyperactivity and the extinction of anxiety-like behaviors.