Altogether, these analyses indicate that three SNPs, consisting of the risk-associated rs1061170, the protection-associated rs800292 and rs12144939, a SNP tagging the CFHR3/1 deletion haplotype, are the most likely causal AMD variants within the CFH-CFHR5 extended region and are sufficient to describe the spectrum of common AMD susceptibility associated with the Chr1 AMD locus among individuals with European ancestry (see Fig. 1b and Supplementary Figs. 2 and 4). This evidence concerns the gene CFHR5 and age-related macular degeneration.