The most common genetic contributors to AMD among individuals with European ancestry are variants associated with a cluster of genes involved in regulation of the alternative complement pathway (AP) on chromosome 1q32 (Chr1 AMD locus) and variants associated with two neighboring genes on chromosome 10q26 (Chr10 AMD locus), age-related maculopathy susceptibility 2 (ARMS2) and high-temperature requirement factor A1 (HTRA1)17,18. Here, HTRA1 is linked to age-related macular degeneration.