We previously showed23 using the Utah & Iowa cohort only that rs1410996 may have been identified as a most likely causal variant at the Chr1 AMD locus by the IAMDGC19 because it tags two independent protective haplotypes carrying an A allele at rs800292, the genetic deletion of CFHR3/1, or (rarely) both. Here, CFHR3 is linked to age-related macular degeneration.