Further, Agrin KD in BXPC3 PDAC cells (Fig. S3E) abrogates the effects of BACE2 inhibition and Aβ40 administration on the expression of YAP target genes, CTGF and CYR61 (Fig. 4E, F), demonstrating that this mechanism is not restricted to melanoma or PMEL amyloid fibrils but it is conserved in pancreatic cancer and can be driven by different types of amyloids, such as Aβ40 amyloids. Here, CCN2 is linked to pancreatic neoplasm.