Further, the overexpression of LATS2 in amyloid-deficient melanoma cells (Fig. S4K, L) does not block the effects of rPMEL amyloid fibrils on CTGF expression (Fig. S4M), indicating that increasing the level of LATS2 is not sufficient to shut down mechanotransduction exerted by PMEL amyloid fibrils. The gene discussed is CCN2; the disease is melanoma.