TNF and rheumatoid arthritis: There was low-quality evidence that age,18–20 22 29 32 33 36 38 42 43 smoking,20–22 24 32 38 43 auto-antibodies associated with RA,20 22 32 36 38 42 disease severity/activity,22 32 36 42 inflammatory markers,22 32 42 disease duration,22 32 36 MTX dose18 20–22 32 36 37 and concomitant anti-TNF-alpha drugs21 22 32 37 were not associated with hepatotoxicity.