CBL mutations have been identified in different myeloid neoplasms including MDS/MPN and acute leukemia but are rarely found in lymphoid malignancies (Caligiuri et al. 2007; Sargin et al. 2007; McKeller et al. 2009; Reindl et al. 2009). The gene discussed is CBL; the disease is myeloproliferative neoplasm.