MFGE8 and type 2 diabetes mellitus: The cellular source for the increased serum levels of MFGE8 in patients with T2D is an interesting question that is challenging to experimentally evaluate given numerous cell types produce MFGE8 (1, 4, 5, 36, 37) and that, as a secreted molecule, MFGE8 can be made by one cell type and passed to an adjacent population that uses, but does not produce, MFGE8 (38).