TP53 and hepatocellular carcinoma: Nanoparticle (NP)-delivered WTp53-mRNA was able to slow the growth of these cells by inducing cell cycle arrest and apoptosis.51 This is a crucial finding as high WTp53 expression has been correlated with improved patient survival in both HCC and NSCLS patients as per the clinical data in TCGA.52,53 Moreover, Shi et al.54 evaluated and optimized a CXCR4-targeted WTp53-mRNA system to induce p53 expression in HCC.