TP53 and cancer: Current therapies focus on mainly three strategies; (i) restore conformation and function of existing mutp53 to those of WTp53, (ii) deplete missense mutp53, and (iii) induce p53 synthetic lethality (Fig. 2).9,13 A recent review by Hu et al.,24 “Targeting mutant p53 for cancer therapy: direct and indirect strategies” gives a comprehensive overview of the strategies developed and currently used.