TRPV1 and Alzheimer disease: In a murine model of AD utilizing a mixture of house dust mite (HDM) and staphylococcal enterotoxin B (SEB), depletion of TRPV1+ nociceptors using the ultrapotent TRPV1 agonist, resiniferatoxin, attenuated HDM+SEB-induced skin pathology and as well as reducing eosinophil, and neutrophil recruitment.14 In this model, HDM is thought to trigger skin sensory neurons directly.