A group of skin sensory neurons, distinct from TRPV1+, express Mrgprd.71 These Mrgprd+ neurons could be maintained by Langerhans cells and promote homeostasis.72 During irritant-induced dermatitis or S. aureus-induced skin infection, the Mrgprd+ neurons were shown to protect against aberrant mast cell activation in response to chemical irritants via their glutamate release. This evidence concerns the gene MRGPRD and skin disorder.