TFEB and neurodegenerative disease: For example, the transcription factor EB (TFEB) (so named for its recognition and binding to E-box motifs) belongs to the family of microphthalmia/transcription factor E (MiT/TFE) genes, has been shown to control expression of genes involved in autophagosome formation and lysosome biogenesis, and has reduced expression in many neurodegenerative diseases (2–4).