The expression of CADM1, CADM3, CDH2 was down-regulated (DSgene < −1.5) while expression of three other genes (CDH15, NRXN2, L1CAM) was up-regulated (DSgene > 1.5) in PDO.1 (S8(B) Fig), compared with average expression of ILC tumor, while we observed better congruence in PDX.1B (S8(A) Fig). Here, L1CAM is linked to neoplasm.