C4B and myeloid neoplasm: To investigate if the identified CH mutations could potentially increase the risk of developing subsequent pathologies (hazardous mutations), we searched for their frequency in two datasets of mutations containing, respectively, all CH mutations published insofar, and the mutations reported in myeloid neoplasms in cBioPortal (https://www.cbioportal.org/, see Supplementary Materials and methods in S1 File for details).