KIT and oral cavity squamous cell carcinoma: A study that analyzed the impact of c-kit+ mast cells in oral squamous cell carcinoma found that the presence of mast cells was associated with reduced disease recurrence.26 To address its potential function, c-kit signals mediate the normal growth and phenotypic differentiation of mast cells by regulating the production of their secretory granules.25 Curiously, we found that the staining pattern of c-kit closely resembled that of toluidine blue and tryptase, confirming the presence of mast cells and excluding a c-kit staining of true pluripotent stromal cells.