PORCN and cancer: Ghrelin O-acyltransferase (GOAT),Porcupine (PORCN), and Hedgehog acyltransferase (HHAT), acylate Ghrelin,Wnt, and Hedgehog proteins, respectively.1,2 Theseacyltransferase enzymes are potential drug targets in type II diabetesand obesity (GOAT), neurodegeneration (PORCN), and cancer (PORCN andHHAT).