Ghrelin O-acyltransferase (GOAT),Porcupine (PORCN), and Hedgehog acyltransferase (HHAT), acylate Ghrelin,Wnt, and Hedgehog proteins, respectively.1,2 Theseacyltransferase enzymes are potential drug targets in type II diabetesand obesity (GOAT), neurodegeneration (PORCN), and cancer (PORCN andHHAT). This evidence concerns the gene MBOAT4 and cancer.