Ghrelin O-acyltransferase (GOAT),Porcupine (PORCN), and Hedgehog acyltransferase (HHAT), acylate Ghrelin,Wnt, and Hedgehog proteins, respectively.1,2 Theseacyltransferase enzymes are potential drug targets in type II diabetesand obesity (GOAT), neurodegeneration (PORCN), and cancer (PORCN andHHAT). Here, MBOAT4 is linked to obesity due to melanocortin 4 receptor deficiency.